[HTML][HTML] A broad and potent H1-specific human monoclonal antibody produced in plants prevents influenza virus infection and transmission in guinea pigs

JG Park, C Ye, MS Piepenbrink, A Nogales, H Wang… - Viruses, 2020 - mdpi.com
… to prevent and treat H1N1 infections. Collectively, this study demonstrated, for the first
time, a plant-produced influenza hMAb with in vitro and in vivo activity against influenza virus. …

[HTML][HTML] Influenza virus glycoprotein-reactive human monoclonal antibodies

Y Li, L Wang, H Si, Z Yu, S Tian, R Xiang, X Deng… - … and Infection, 2020 - Elsevier
… can effectively prevent the spread of the virus. In this review, … Influenza viruses are easily
transmitted by droplets, but only … This is the first time that a plant-based human mAb had been …

[HTML][HTML] Animal models for influenza research: strengths and weaknesses

TQ Nguyen, R Rollon, YK Choi - Viruses, 2021 - mdpi.com
… Following infection of guinea pigs, the influenza virus mainly … plant-produced influenza
human monoclonal antibody on preventing influenza infection and transmission in guinea

Evaluation of panel of neutralising murine monoclonal antibodies and a humanised bispecific antibody against influenza A (H1N1) pdm09 virus infection in a mouse …

F Yang, S Yan, L Zhu, FXC Wang, F Liu, L Cheng… - Antiviral Research, 2022 - Elsevier
… A(H1N1) pdm09 influenza viruses, we generated 15 murine … mAbs, was also effective in
preventing and treating A(H1N1) … and therapeutic potency in a mouse infection model of A/…

Reducing influenza virus transmission: the potential value of antiviral treatment

FG Hayden, J Asher, BJ Cowling… - Clinical Infectious …, 2022 - academic.oup.com
… anti-hemagglutinin head monoclonal antibody [11]. When this … guinea pigs 24 hours after
infection with A/H1N1pdm09 virus… of baloxavir in preventing direct contact transmission. The …

[HTML][HTML] Emergence of novel coronavirus 2019-nCoV: need for rapid vaccine and biologics development

B Shanmugaraj, A Malla, W Phoolcharoen - Pathogens, 2020 - mdpi.com
Human-to-human transmission is reported in countries such as … As of now, preventing
infection is the current priority for … antigens and monoclonal antibodies expressed in plants. …

Influenza hemagglutinin-specific IgA Fc-effector functionality is restricted to stalk epitopes

AW Freyn, J Han, JJ Guthmiller… - Proceedings of the …, 2021 - National Acad Sciences
… a panel of human monoclonal antibodies (mAbs) derived … To assess the ability of our
H1-specific antibody panel to elicit Fc-… antibodies have also been shown to prevent influenza virus

Enhanced ability of plant-derived PGT121 glycovariants to eliminate HIV-1-Infected cells

SP Anand, S Ding, WD Tolbert, J Prévost… - Journal of …, 2021 - Am Soc Microbiol
… to produce different Fc-glycovariants of a potent bNAb, PGT121… to increase the production
of monoclonal antibody (MAb) … , resulting in a premature stop codon followed by a frameshift. …

[HTML][HTML] Neuraminidase delivered as an APC-targeted DNA vaccine induces protective antibodies against influenza

IC Werninghaus, DM Hinke, E Fossum, B Bogen… - Molecular Therapy, 2023 - cell.com
… /c mice elicited strong and long-lasting NA-specific antibodies that inhibited NA enzymatic …
Vaccine-induced NA immunity completely protected against a homologous influenza virus and …

[HTML][HTML] Nasal IgA provides protection against human influenza challenge in volunteers with low serum influenza antibody titre

VMW Gould, JN Francis, KJ Anderson… - Frontiers in …, 2017 - frontiersin.org
H1 specific IgA responses were measured by ELISA in serum on day-1 and day 29 of … by
studies in guinea pig models demonstrating that IgA prevents influenza transmission (Seibert et …